Endocrine Abstracts

Objectives: A sporadic association between thyroid and non-organ-specific autoimmunity has been reported, which could be relevant for Graves’ orbitopathy (GO), an autoimmune disease affecting orbital connective tissue. We investigated whether there is an association between GO and anti-nuclear antibodies (ANAs).Methods: We performed a cross-sectional investigation in 265 consecutive patients with Graves’ disease (GD) who came to our observation...

Background: The COVID-19 pandemic has adversely affected population mental health. In April 2021 we conducted an observational study which demonstrated disruption in women’s reproductive and mental health during the first year of the pandemic. Our objective therefore was to perform follow up studies in this cohort of women at 6-monthly intervals, to assess the longer term enduring impact of the pandemic on reproductive and mental health.Materials/Me...

Defects in any of the four functional domains of the androgen receptor (AR) (resulting from loss-of-function or gain-of-function mutations), may affect androgen action. Specific AR splice variants have been reported in women with PCOS (Wang et al, PNAS 2015 112 4743). In this study we sought to identify AR splice variants in granulosa-lutein (GL) cells of women with and without PCOS and to assess their functional significance. GL cells were ...

Background: People with Primary adrenal insufficiency (PAI) were identified as a vulnerable group by the UK government during the COVID-19 pandemic. Hence our aim was to evaluate the incidence of COVID-19, and associated adrenal crisis (AC) in people with PAI in the UK.Methods: A prospective observational study of patients with PAI was performed between January-June 2022. Participants were recruited via the Addison’s Disease Self Help Group. Diagnos...

Polycystic Ovary Syndrome (PCOS) is the most common endocrinological dysfunction among women of reproductive age, often featuring hyperandrogenemia and anovulation. Reciprocal effects exist between elevated LH, androgens, anovulation and other features, increasing the hormonal disbalance, while the origins of PCOS are still not fully clear. The neuropeptides Phoenixin-20 (PNX20) and Nesfatin1 (NES1) are being co-expressed and thought to play opposing roles in the hypothalamic&...

Endocrine-Related Cancer, 2018, 25(2): 131–144 (DOI: https://doi.org/10.1530/ERC-17-0415)...

Patients with sellar masses (SM) undergoing transsphenoidal surgery (TSS) have a significant risk of transient or permanent endocrine dysfunction; therefore, in-hospital endocrinology consultation (IHEC) is recommended for these patients. However, routine assessment of all TSS patients by a specialized team is not feasible outside select centers. We developed an IHEC guide for TSS patients in December 2015 to identify those patients who would require perioperative IHEC. We con...

Background: Severe maternal hypothyroidism during pregnancy may be associated with delayed development and lower IQ in the foetus. BES (2007) and NICE (2011) guidelines recommend maintaining TSH<2.5 mU/l with monitoring of maternal thyroid function test (TFT) 4 weekly, especially in the first trimester.Aim and methods: A retrospective study on all pregnant women with established hypothyroidism attending the Joint Antenatal Clinic (JANC) at Liverpool ...

Introduction: Polycystic ovary syndrome (PCOS) is a hyperandrogenic endocrine disorder associated with chronic oligo-amenorrhea, hirsutism, polycystic ovary morphology (PCOM) and often with insulin resistance. Due to its heterogenic etiology, there is no general treatment, but rather an individual approach, according to patient’s symptoms, needs and wishes. The aim of this study is to detect possible variations in clinical and biochemical outcome in PCOS cases, after trea...

Background: Although pheochromocytoma classically presents with headaches, palpitations and paroxysmal hypertension, uncommon presentations such as cardiomyopathy, stroke and subarachnoid haemorrhage have been documented. We present one such infrequent presentation of myocardial infarction with normal coronary arteries (MINOCA).Case presentation: A 79-year Caucasian female presented with central crushing chest pain radiating to left arm associated with h...